BMAL1 promotes colorectal cancer cell migration and invasion through ERK- and JNK-dependent c-Myc expression.

Lina ShanWenqian ZhengBingjun BaiJinghui HuYiming LvKangke ChenXiaowei WangYangtao PanXuefeng Huang Hongbo Zhu Sheng Dai

Published in: Cancer medicine (2022)

Our study showed that BMAL1 promotes CRC metastasis through MAPK-c-Myc pathway. These results deepen our understanding of the relationship between BMAL1 and tumorigenic phenotypes, which may become a promising therapeutic target for BMAL1 overexpressing CRC.

Keyphrases

signaling pathway
pi k akt
poor prognosis
cell proliferation
cell death
oxidative stress
induced apoptosis
binding protein