Scleral remodeling during myopia development in mice eyes: a potential role of thrombospondin-1.

Junhan ChenShin-Ichi IkedaYajing YangYan ZhangZiyan MaYifan LiangKazuno NegishiKazuo TsubotaToshihide Kurihara

Published in: Molecular medicine (Cambridge, Mass.) (2024)

Our findings indicate that sclera THBS1 levels decreased during myopia development and subsequent THBS1 knockdown showed a decrease in scleral COLA1 expression. Taken together, these results suggest that THBS1 plays a role in maintaining the homeostasis of scleral extracellular matrix, and the reduction of THBS1 may promote the remodeling process and then affect ocular axial elongation during myopia progression.

Keyphrases

extracellular matrix
optic nerve
poor prognosis
optical coherence tomography
metabolic syndrome
binding protein
risk assessment
skeletal muscle
human health
long non coding rna