Identification of lysyl oxidase as an adipocyte-secreted mediator that promotes a partial mesenchymal-to-epithelial transition in MDA-MB-231 cells.
Cassidy M Van StiphoutGrant KellyNikitha K PallegarEman ElbakryAna Valeria Vilchis-CelisSherri L ChristianAlicia M Viloria-PetitPublished in: Exploration of targeted anti-tumor therapy (2024)
The data suggest that adipocyte-secreted LOX changes the mesenchymal phenotype of BC cells in a manner that could promote secondary tumour formation, particularly at sites high in adipocytes such as the bone marrow. Future efforts should focus on determining whether targeting LOX could reduce BC metastasis in obese individuals.
Keyphrases
- bone marrow
- adipose tissue
- cell cycle arrest
- induced apoptosis
- stem cells
- insulin resistance
- cell death
- type diabetes
- fatty acid
- mesenchymal stem cells
- metabolic syndrome
- oxidative stress
- weight loss
- current status
- big data
- machine learning
- pi k akt
- cancer therapy
- skeletal muscle
- obese patients
- bariatric surgery
- quality improvement
- low density lipoprotein