Remote conformational responses to enantiomeric excess in carboxylate-binding dynamic foldamers.

Natasha EcclesBryden A F Le BaillyFlavio Della SalaIñigo J Vitórica-YrezábalJonathan Clayden Simon J Webb

Published in: Chemical communications (Cambridge, England) (2019)

A crystallographically characterised zinc(ii)-capped foldamer can sense the enantiomeric excess of scalemic carboxylate solutions, including those produced by enantioselective organocatalysis, and can relay this input signal along the foldamer body to a remote glycinamide group, which then provides an NMR spectroscopic output.

Keyphrases

capillary electrophoresis
molecular docking
magnetic resonance
molecular dynamics simulations
high resolution
molecular dynamics
single molecule
solid state
mass spectrometry
dna binding
transcription factor