Targeting aberrant fatty acid synthesis and storage in endocrine resistant breast cancer cells.
Ashley V WardDuncan RileyJessica Finlay-SchultzHeather M BrechbuhlKaitlyn B HillRohan R VarshneyPeter KabosMichael C RudolphCarol A SartoriusPublished in: bioRxiv : the preprint server for biology (2024)
ET resistant breast cancer cells exhibit a shift towards enhanced triglyceride storage and complex lipids enriched with PUFA acyl chains. While targeting FASN alongside ET may not fully overcome ET resistance in our models, focusing on the unique lipid metabolic dependencies, such as PUFA pathways, may present a promising alternative strategy for treating ET resistant breast cancer.