Sex differences in distribution and identity of aromatase gene expressing cells in the young adult rat brain.

Jana ImmenschuhStefan Bernhard ThalhammerInger Sundström-PoromaaAnat BiegonSylvie DumasErika Comasco

Published in: Biology of sex differences (2023)

Females show overall a lower number of cells expressing Cyp19a1 in the limbic brain. In both sexes, aromatase is expressed in a region-specific manner in GABAergic and glutamatergic neurons. These findings call for investigations of the relevance of sex-specific and region-dependent expression of Cyp19a1 in the limbic brain to sex differences in behavior and mental health.

Keyphrases

induced apoptosis
mental health
cell cycle arrest
young adults
resting state
white matter
poor prognosis
spinal cord
functional connectivity
endoplasmic reticulum stress
signaling pathway
genome wide
gene expression
dna methylation
multiple sclerosis
cerebral ischemia
binding protein