Quercetin alleviates chronic unpredictable mild stress-induced depression-like behavior by inhibiting NMDAR1 with α2δ-1 in rats.

Mingyan WangXin WeiYugai JiaChaonan WangXinliu WangXin ZhangDepei LiYuanyuan WangYonggang Gao

Published in: CNS neuroscience & therapeutics (2024)

Que has a good antidepressant effect and can significantly improve the depression-like behavior caused by CUMS. It exerts antidepressant effects by inhibiting the expression level of α2δ-1, interfering with the interaction between α2δ-1 and NMDAR, and then reducing the excitability of the HPA axis.

Keyphrases

stress induced
major depressive disorder
depressive symptoms
signaling pathway
sleep quality
poor prognosis
binding protein
physical activity
drug induced