Restriction of extracellular lipids renders pancreatic cancer dependent on autophagy.

Maria SaliakouraMatteo Rossi SebastianoIoanna NikdimaChiara PozzatoGeorgia Konstantinidou

Published in: Journal of experimental & clinical cancer research : CR (2022)

Our work unravels a central role of extracellular lipid supply in ensuring fatty acid provision in cancer cells, unmasking a previously unappreciated metabolic vulnerability of PDAC cells.

Keyphrases

fatty acid
induced apoptosis
endoplasmic reticulum stress
cell cycle arrest
cell death
signaling pathway
oxidative stress
climate change
palliative care
pi k akt
cell proliferation