Low tumor cell content predicts favorable prognosis in germinoma patients.
Hirokazu TakamiKaishi SatomiKohei FukuokaShintaro FukushimaYuko MatsushitaKai YamasakiTaishi NakamuraShota TanakaAkitake MukasaNobuhito SaitoTomonari SuzukiTakaaki YanagisawaHideo NakamuraKazuhiko SugiyamaKaoru TamuraTaketoshi MaeharaMitsutoshi NakadaMasahiro NonakaAkio AsaiKiyotaka YokogamiHideo TakeshimaToshihiko IuchiYonehiro KanemuraKeiichi KobayashiMotoo NaganeKazuhiko KurozumiKoji YoshimotoMasahide MatsudaAkira MatsumuraYuichi HiroseTsutomu TokuyamaToshihiro KumabeYoshitaka NaritaSoichiro ShibuiYoichi NakazatoRyo NishikawaMasao MatsutaniKoichi IchimuraPublished in: Neuro-oncology advances (2021)
We found that tumor cell content significantly affected the prognosis of germinomas. Although validation of these results using an independent and larger cohort is necessary, this potentially opens the possibility of leveraging this pathological factor in future clinical trials when stratifying the treatment intensity.