High intensity AE elicits greater increases in circulating CTSB compared with lower intensities. Skeletal muscle protein and gene expression corroborate the potential role of skeletal muscle in generating and releasing neuroprotective exerkines into the circulation.NEW AND NOTEWORTHY: 1) CTSB is enriched in the circulation in an aerobic exercise intensity dependent manner. 2) Skeletal muscle tissue expresses both message and protein of CTSB and BDNF. 3) BDNF is highly expressed in glycolytic skeletal muscle fibers.
Keyphrases
- subarachnoid hemorrhage
- skeletal muscle
- high intensity
- brain injury
- insulin resistance
- gene expression
- resistance training
- poor prognosis
- binding protein
- type diabetes
- liver failure
- stress induced
- dna methylation
- protein protein
- climate change
- blood brain barrier
- body composition
- small molecule
- mechanical ventilation
- acute respiratory distress syndrome
- aortic dissection