Systematic evaluation of transcriptomic disease risk and diagnostic biomarker overlap between COVID-19 and tuberculosis: a patient-level meta-analysis.

Dylan Sheerinnull AbhimanyuXutao WangW Evan JohnsonAnna K Coussens

Published in: medRxiv : the preprint server for health sciences (2020)

Our results identify shared dysregulation of immune responses in COVID-19 and TB as a dual risk posed by co-infection to COVID-19 severity and TB disease progression. These individuals should be followed up for TB in the months subsequent to SARS-CoV-2 diagnosis.

Keyphrases

sars cov
coronavirus disease
mycobacterium tuberculosis
respiratory syndrome coronavirus
systematic review
immune response
pulmonary tuberculosis
randomized controlled trial
single cell
rna seq
inflammatory response
dendritic cells
meta analyses
toll like receptor
hepatitis c virus