Human macrophages differentiated in the presence of vitamin D3 restrict dengue virus infection and innate responses by downregulating mannose receptor expression.
John F Arboleda AlzateIzabela A Rodenhuis-ZybertJuan C HernándezJolanda M SmitSilvio Urcuqui-InchimaPublished in: PLoS neglected tropical diseases (2017)
Our findings reveal a molecular mechanism by which vitamin D counteracts DENV infection and progression of severe disease, and indicates its potential relevance as a preventive or therapeutic candidate.