ADAR3 expression is an independent prognostic factor in lower-grade diffuse gliomas and positively correlated with the editing level of GRIA2Q607R.

Ying ZhangKuanyu WangZheng ZhaoSi SunKenan ZhangRuoyu HuangFan ZengHuimin Hu

Published in: Cancer cell international (2018)

Our study demonstrated the clinical and molecular characterization of ADAR3 in glioma development and progression. ADAR3 expression was negatively associated with tumor malignant in the overall glioma patients. And it was a favorable independent prognostic indicator of LGG patients. ADAR3 appeared to act as a tumor suppressor in glioma cells. Therefore, ADAR3 represented a potential therapeutic target and useful prognostic factor for glioma patients.

Keyphrases

prognostic factors
end stage renal disease
chronic kidney disease
newly diagnosed
poor prognosis
peritoneal dialysis
crispr cas
high grade
low grade
human health