Post genome-wide gene-environment interaction study: The effect of genetically driven insulin resistance on breast cancer risk using Mendelian randomization.

Su Yon JungNicholas MancusoJeanette PappEric SobelZuo-Feng Zhang

Published in: PloS one (2019)

We found complex evidence for causal association between IR and risk of breast cancer, which may support the potential value of intervention trials to lower IR and reduce breast cancer risk.

Keyphrases

breast cancer risk
genome wide
insulin resistance
dna methylation
randomized controlled trial
copy number
type diabetes
adipose tissue
metabolic syndrome
high fat diet
gene expression
polycystic ovary syndrome