TIMP-1 Promotes Expression of MCP-1 and Macrophage Migration by Inducing Fli-1 in Experimental Liver Fibrosis.

Xiaoli HuangXiaofan WangYanhong WangShuangjun ShenWei ChenTianhui LiuPing WangXu FanLin LiuJidong JiaMin Cong

Published in: Journal of clinical and translational hepatology (2024)

TIMP-1 induces Fli-1 expression through miRNA-145, subsequently increasing MCP-1 expression and macrophage recruitment. MiRNA-145-enriched EVs from HSCs can transmit biological information and magnify the function of TIMP-1.

Keyphrases

poor prognosis
liver fibrosis
adipose tissue
long non coding rna
healthcare
social media
health information