Revealing Individual Neuroanatomical Heterogeneity in Alzheimer Disease Using Neuroanatomical Normative Modeling.
Serena VerdiSeyed Mostafa KiaKeir X X YongDuygu TosunJonathan M SchottAndre F MarquandJames H ColePublished in: Neurology (2023)
Individualised normative maps of cortical thickness highlight the heterogeneous impact of AD on the brain. Regional outlier estimates have the potential to be a marker of disease and could be used to track an individual's disease progression or treatment response in clinical trials.