HIV DNA reservoir and elevated PD-1 expression of CD4 T-cell subsets particularly persist in the terminal ileum of HIV-positive patients despite cART.
Carola HornM AugustinM S ErcanogluE HegerE KnopsV BondetD DuffySeung-Hun ChonD NierhoffM OetteH SchäferC VivaldiK HeldJ AndersonC GeldmacherI SuárezJ RybnikerF KleinG FätkenheuerM Müller-TrutwinC LehmannPublished in: HIV medicine (2021)
Elevated PD-1 expression on memory CD4 T-cells in PB and TI despite treatment points to continuous immune dysfunction and underlines the importance of evaluating immunotherapy in reversing HIV latency and T-cell reconstitution. As HIV DNA particularly persists in TI despite cART, investigating samples from TI is crucial in understanding HIV immunopathogenesis.
Keyphrases
- hiv positive
- antiretroviral therapy
- men who have sex with men
- south africa
- hiv infected
- hiv testing
- human immunodeficiency virus
- hiv aids
- poor prognosis
- end stage renal disease
- ejection fraction
- newly diagnosed
- circulating tumor
- cell free
- single molecule
- binding protein
- peritoneal dialysis
- prognostic factors
- oxidative stress
- working memory
- nucleic acid