Sensitivity of 18F-fluorodihydrotestosterone PET-CT to count statistics and reconstruction protocol in metastatic castration-resistant prostate cancer.
Matthijs C F CysouwGerbrand M KramerDennis HeijtelRobert C SchuitMichael J MorrisAlfons J M van den EertweghJens VoortmanOtto S HoekstraDaniela E Oprea-LagerRonald BoellaardPublished in: EJNMMI research (2019)
Reducing [18F]FDHT PET acquisition time from 3 min to 1.5 per bed position resulted in a repeatability of SUVpeak (bodyweight) remaining ≤ 30%, which is generally acceptable for response monitoring purposes. However, EARL2 reconstruction was more affected, especially for SUVmax whose repeatability tended to exceed 30%. Lesion detectability was only slightly impaired by reducing acquisition time, which might not be clinically relevant in mCRPC.