Pediatric ECMO: unfavorable outcomes are associated with inflammation and endothelial activation.
Sherrill D CaprarolaDerek K NgMegan K CarrollAylin TekesRyan J FellingCynthia F SalorioReem AlmuqatiJamie M SchwartzAllen D EverettMelania M BembeaPublished in: Pediatric research (2021)
The inflammatory, endothelial activation, and fibrinolytic profile of children on ECMO differs by primary indication for extracorporeal support. Proinflammatory biomarkers on ECMO day 1 are associated with abnormal neurologic imaging in children on ECMO in univariable but not multivariable models. In multivariable models, a pronounced proinflammatory and prothrombotic biomarker profile on ECMO day 1 and longitudinally was significantly associated with mortality. Further studies are needed to identify inflammatory, endothelial, and fibrinolytic profiles associated with increased risk for neurologic injury and mortality through potential mediation of bleeding and thrombosis.
Keyphrases
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- respiratory failure
- oxidative stress
- endothelial cells
- mechanical ventilation
- young adults
- cardiovascular events
- high resolution
- pulmonary embolism
- risk factors
- intensive care unit
- social support
- coronary artery disease
- depressive symptoms
- metabolic syndrome
- insulin resistance
- photodynamic therapy
- skeletal muscle
- weight loss