Caveolin-1-driven membrane remodelling regulates hnRNPK-mediated exosomal microRNA sorting in cancer.
Harley R RobinsonJayde E RuelckeAmanda LewisCharles S BondArcha H FoxVandhana BhartiShivangi WaniNicole CloonanAndrew LaiDavid MargolinLi LiCarlos Salomon GalloRenee S RichardsAine FarrellRobert A GardinerRobert G PartonAlexandre S CristinoMichelle M HillPublished in: Clinical and translational medicine (2022)
Taken together, these results support a novel pan-cancer mechanism for CAV1-driven exosomal release of hnRNPK and associated miRNA in metastasis, which is modulated by the membrane lipid environment.