Early Changes in Striatal Activity and Motor Kinematics in a Huntington's Disease Mouse Model.

Ellen T KochMarja D SepersJudy ChengLynn A Raymond

Published in: Movement disorders : official journal of the Movement Disorder Society (2022)

We uncovered impaired motor coordination at a stage thought to be premotor manifest in YAC128 mice and aberrant striatal activity during the accelerating rotarod and open-field exploration. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

mouse model
parkinson disease
functional connectivity
minimally invasive
randomized controlled trial
type diabetes
high fat diet induced
adipose tissue
metabolic syndrome