Regulation of Three Virulence Strategies of Mycobacterium tuberculosis: A Success Story.
Niels A ZondervanJesse C J van DamPeter J SchaapVitor A P Martins Dos SantosMaria Suarez-DiezPublished in: International journal of molecular sciences (2018)
Tuberculosis remains one of the deadliest diseases. Emergence of drug-resistant and multidrug-resistant M. tuberculosis strains makes treating tuberculosis increasingly challenging. In order to develop novel intervention strategies, detailed understanding of the molecular mechanisms behind the success of this pathogen is required. Here, we review recent literature to provide a systems level overview of the molecular and cellular components involved in divalent metal homeostasis and their role in regulating the three main virulence strategies of M. tuberculosis: immune modulation, dormancy and phagosomal rupture. We provide a visual and modular overview of these components and their regulation. Our analysis identified a single regulatory cascade for these three virulence strategies that respond to limited availability of divalent metals in the phagosome.
Keyphrases
- mycobacterium tuberculosis
- drug resistant
- multidrug resistant
- escherichia coli
- pulmonary tuberculosis
- pseudomonas aeruginosa
- staphylococcus aureus
- acinetobacter baumannii
- biofilm formation
- antimicrobial resistance
- hiv aids
- gram negative
- randomized controlled trial
- systematic review
- candida albicans
- transcription factor
- adverse drug
- emergency department
- cystic fibrosis
- climate change
- heavy metals