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Impact of reduced P-glycoprotein function on digoxin concentrations in patients with dementia.

Izna AliDaniel GuidoneJoseph A NicolazzoKim L R Brouwer
Published in: British journal of clinical pharmacology (2019)
Clinically measured digoxin concentrations were not statistically different in patients with dementia. Based on PBPK simulations, digoxin AUC may need to be evaluated to adequately assess the impact of reduced P-gp function in peripheral organs.
Keyphrases
  • mild cognitive impairment
  • cognitive impairment
  • molecular dynamics