Kim L R Brouwer

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 39

Top Topics

Decision Making

Cognitive Impairment

Top Venues

Clinical pharmacology and therapeutics

Toxicological sciences : an official journal of the Society of Toxicology

Drug metabolism and disposition: the biological fate of chemicals

Hepatology communications

This page only lists publications with an associated author ORCID identifier.

Publications

Ena Vujic, Stephen S Ferguson, Kim L R Brouwer
Effects of PFAS on human liver transporters: implications for health outcomes. Toxicological sciences : an official journal of the Society of Toxicology 200 (2) (2024)
Mattie Hartauer, William A Murphy, Kim L R Brouwer, Roz Southall, Sibylle Neuhoff
Hepatic OATP1B zonal distribution: Implications for rifampicin-mediated drug-drug interactions explored within a PBPK framework. CPT: pharmacometrics & systems pharmacology (2024)
Jeffry Adiwidjaja, Jessica Spires, Kim L R Brouwer
Physiologically Based Pharmacokinetic (PBPK) Model Predictions of Disease Mediated Changes in Drug Disposition in Patients with Nonalcoholic Fatty Liver Disease (NAFLD). Pharmaceutical research (2024)
Ena Vujic, Stephen S Ferguson, Kim L R Brouwer
Effects of PFAS on human liver transporters: implications for health outcomes. Toxicological sciences : an official journal of the Society of Toxicology 200 (2) (2024)
William A Murphy, Anna Mae Diehl, Matthew Shane Loop, Dong Fu, Cynthia D Guy, Manal F Abdelmalek, Georgia Sofia Karachaliou, Noora Sjöstedt, Sibylle Neuhoff, Paavo Honkakoski, Kim L R Brouwer
Alterations in zonal distribution and plasma membrane localization of hepatocyte bile acid transporters in patients with NAFLD. Hepatology communications 8 (3) (2024)
William A Murphy, Anna Mae Diehl, Matthew Shane Loop, Dong Fu, Cynthia D Guy, Manal F Abdelmalek, Georgia Sofia Karachaliou, Noora Sjöstedt, Sibylle Neuhoff, Paavo Honkakoski, Kim L R Brouwer
Alterations in zonal distribution and plasma membrane localization of hepatocyte bile acid transporters in patients with NAFLD. Hepatology communications 8 (3) (2024)
William A Murphy, Anna Mae Diehl, Matthew Shane Loop, Dong Fu, Cynthia D Guy, Manal F Abdelmalek, Georgia Sofia Karachaliou, Noora Sjöstedt, Sibylle Neuhoff, Paavo Honkakoski, Kim L R Brouwer
Alterations in zonal distribution and plasma membrane localization of hepatocyte bile acid transporters in patients with NAFLD. Hepatology communications 8 (3) (2024)
Aleksandra Galetin, Kim L R Brouwer, Donald Tweedie, Kenta Yoshida, Noora Sjöstedt, Lauren M Aleksunes, Xiaoyan Chu, Raymond Evers, Michael J Hafey, Yurong Lai, Pär Matsson, Andrew M Riselli, Hong Shen, Alex Sparreboom, Manthena V S Varma, Jia Yang, Xinning Yang, Sook Wah Yee, Maciej J Zamek-Gliszczynski, Lei Zhang, Kathleen M Giacomini
Membrane transporters in drug development and as determinants of precision medicine. Nature reviews. Drug discovery 23 (4) (2024)
Jeffry Adiwidjaja, Jessica Spires, Kim L R Brouwer
Physiologically Based Pharmacokinetic (PBPK) Model Predictions of Disease Mediated Changes in Drug Disposition in Patients with Nonalcoholic Fatty Liver Disease (NAFLD). Pharmaceutical research 41 (3) (2024)
Aleksandra Galetin, Kim L R Brouwer, Donald Tweedie, Kenta Yoshida, Noora Sjöstedt, Lauren M Aleksunes, Xiaoyan Chu, Raymond Evers, Michael J Hafey, Yurong Lai, Pär Matsson, Andrew M Riselli, Hong Shen, Alex Sparreboom, Manthena V S Varma, Jia Yang, Xinning Yang, Sook Wah Yee, Maciej J Zamek-Gliszczynski, Lei Zhang, Kathleen M Giacomini
Membrane transporters in drug development and as determinants of precision medicine. Nature reviews. Drug discovery 23 (4) (2024)
Ena Vujic, Stephen S Ferguson, Kim L R Brouwer
Effects of PFAS on human liver transporters: implications for health outcomes. Toxicological sciences : an official journal of the Society of Toxicology 200 (2) (2024)
Jeffry Adiwidjaja, Jessica Spires, Kim L R Brouwer
Physiologically Based Pharmacokinetic (PBPK) Model Predictions of Disease Mediated Changes in Drug Disposition in Patients with Nonalcoholic Fatty Liver Disease (NAFLD). Pharmaceutical research 41 (3) (2024)
Aleksandra Galetin, Kim L R Brouwer, Donald Tweedie, Kenta Yoshida, Noora Sjöstedt, Lauren M Aleksunes, Xiaoyan Chu, Raymond Evers, Michael J Hafey, Yurong Lai, Pär Matsson, Andrew M Riselli, Hong Shen, Alex Sparreboom, Manthena V S Varma, Jia Yang, Xinning Yang, Sook Wah Yee, Maciej J Zamek-Gliszczynski, Lei Zhang, Kathleen M Giacomini
Membrane transporters in drug development and as determinants of precision medicine. Nature reviews. Drug discovery (2024)
William A Murphy, Anna Mae Diehl, Matthew Shane Loop, Dong Fu, Cynthia D Guy, Manal F Abdelmalek, Georgia Sofia Karachaliou, Noora Sjöstedt, Sibylle Neuhoff, Paavo Honkakoski, Kim L R Brouwer
Alterations in zonal distribution and plasma membrane localization of hepatocyte bile acid transporters in patients with NAFLD. Hepatology communications 8 (3) (2024)
Ena Vujic, Stephen S Ferguson, Kim L R Brouwer
Effects of PFAS on human liver transporters: implications for health outcomes. Toxicological sciences : an official journal of the Society of Toxicology (2024)
Aleksandra Galetin, Kim L R Brouwer, Donald Tweedie, Kenta Yoshida, Noora Sjöstedt, Lauren M Aleksunes, Xiaoyan Chu, Raymond Evers, Michael J Hafey, Yurong Lai, Pär Matsson, Andrew M Riselli, Hong Shen, Alex Sparreboom, Manthena V S Varma, Jia Yang, Xinning Yang, Sook Wah Yee, Maciej J Zamek-Gliszczynski, Lei Zhang, Kathleen M Giacomini
Membrane transporters in drug development and as determinants of precision medicine. Nature reviews. Drug discovery 23 (4) (2024)
Mattie Hartauer, William A Murphy, Kim L R Brouwer, Roz Southall, Sibylle Neuhoff
Hepatic OATP1B zonal distribution: Implications for rifampicin-mediated drug-drug interactions explored within a PBPK framework. CPT: pharmacometrics & systems pharmacology (2024)
Angela Jeong, Catherine M Pastor, Kim L R Brouwer
Application of Pharmacokinetic Modeling to Characterize Hepatobiliary Disposition of Imaging Agents and Alterations due to Liver Injury in Isolated Perfused Rat Livers. Pharmaceutical research (2023)
Kunal S Taskar, Xinning Yang, Sibylle Neuhoff, Mitesh Patel, Kenta Yoshida, Mary F Paine, Kim L R Brouwer, Xiaoyan Chu, Yuichi Sugiyama, Jack Cook, Joseph W Polli, Imad Hanna, Yurong Lai, Maciej Zamek-Gliszczynski, null null
Clinical Relevance of Hepatic and Renal P-gp/BCRP Inhibition of Drugs: An International Transporter Consortium Perspective. Clinical pharmacology and therapeutics 112 (3) (2022)
William A Murphy, Jeffry Adiwidjaja, Noora Sjöstedt, Kyunghee Yang, James J Beaudoin, Jessica Spires, Scott Q Siler, Sibylle Neuhoff, Kim L R Brouwer
Considerations for Physiologically Based Modeling in Liver Disease: From Nonalcoholic Fatty Liver (NAFL) to Nonalcoholic Steatohepatitis (NASH). Clinical pharmacology and therapeutics (2022)
Thomas Kralj, Raju Khatri, Kenneth R Brouwer, Kim L R Brouwer, Darren John Creek
Lipidomics profiles in hepatocytes from nonalcoholic steatohepatitis patients differ markedly from in vitro-induced steatotic hepatocytes. FEBS letters 596 (11) (2022)
Chitra Saran, Dong Fu, Henry Ho, Abigail Klein, John K Fallon, Paavo Honkakoski, Kim L R Brouwer
A novel differentiated HuH-7 cell model to examine bile acid metabolism, transport and cholestatic hepatotoxicity. Scientific reports 12 (1) (2022)
Kim L R Brouwer, Raymond Evers, Elizabeth Hayden, Shuiying Hu, Cindy Yanfei Li, Henriette E Meyer Zu Schwabedissen, Sibylle Neuhoff, Stefan Oswald, Micheline Piquette-Miller, Chitra Saran, Noora Sjöstedt, Jason A Sprowl, Simone H Stahl, Wei Yue
Regulation of Drug Transport Proteins-From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium. Clinical pharmacology and therapeutics 112 (3) (2022)
Yijun Pan, Kotaro Omori, Izna Ali, Masanori Tachikawa, Tetsuya Terasaki, Kim L R Brouwer, Joseph A Nicolazzo
Correction to Altered Expression of Small Intestinal Drug Transporters and Hepatic Metabolic Enzymes in a Mouse Model of Familial Alzheimer's Disease. Molecular pharmaceutics 18 (10) (2021)
Thomas Kralj, Kim L R Brouwer, Darren John Creek
Analytical and Omics-Based Advances in the Study of Drug-Induced Liver Injury. Toxicological sciences : an official journal of the Society of Toxicology 183 (1) (2021)
William A Murphy, James J Beaudoin, Tuomo Laitinen, Noora Sjöstedt, Melina M Malinen, Henry Ho, Peter W Swaan, Paavo Honkakoski, Kim L R Brouwer
Identification of Key Amino Acids that Impact Organic Solute Transporter α/β (OSTα/β). Molecular pharmacology 100 (6) (2021)
James J Beaudoin, William J Brock, Paul B Watkins, Kim L R Brouwer
Quantitative Systems Toxicology Modeling Predicts that Reduced Biliary Efflux Contributes to Tolvaptan Hepatotoxicity. Clinical pharmacology and therapeutics 109 (2) (2020)
Katsuaki Ito, Noora Sjöstedt, Melina M Malinen, Cen Guo, Kim L R Brouwer
Hepatic Transporter Alterations by Nuclear Receptor Agonist T0901317 in Sandwich-Cultured Human Hepatocytes: Proteomic Analysis and PBPK Modeling to Evaluate Drug-Drug Interaction Risk. The Journal of pharmacology and experimental therapeutics 373 (2) (2020)
Maciej J Zamek-Gliszczynski, Mitesh Patel, Xinning Yang, Justin D Lutz, Xiaoyan Chu, Kim L R Brouwer, Yurong Lai, Caroline A Lee, Sibylle Neuhoff, Mary F Paine, Yuichi Sugiyama, Kunal S Taskar, Aleksandra Galetin
Intestinal P-gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications. Clinical pharmacology and therapeutics 109 (1) (2020)
Liang Jin, Yijun Pan, Natalie Lan Linh Tran, Leon N Polychronopoulos, Aparna Warrier, Kim L R Brouwer, Joseph A Nicolazzo
Intestinal Permeability and Oral Absorption of Selected Drugs Are Reduced in a Mouse Model of Familial Alzheimer's Disease. Molecular pharmaceutics 17 (5) (2020)
Noora Sjöstedt, Sibylle Neuhoff, Kim L R Brouwer
Physiologically-Based Pharmacokinetic Model of Morphine and Morphine-3-Glucuronide in Nonalcoholic Steatohepatitis. Clinical pharmacology and therapeutics 109 (3) (2020)
Izna Ali, Daniel Guidone, Joseph A Nicolazzo, Kim L R Brouwer
Impact of reduced P-glycoprotein function on digoxin concentrations in patients with dementia. British journal of clinical pharmacology 85 (10) (2019)
Jacqueline Bezençon, James J Beaudoin, Katsuaki Ito, Dong Fu, Sharin E Roth, William J Brock, Kim L R Brouwer
Altered Expression and Function of Hepatic Transporters in a Rodent Model of Polycystic Kidney Disease. Drug metabolism and disposition: the biological fate of chemicals 47 (8) (2019)
Hee Eun Kang, Melina M Malinen, Chitra Saran, Paavo Honkakoski, Kim L R Brouwer
Optimization of Canalicular ABC Transporter Function in HuH-7 Cells by Modification of Culture Conditions. Drug metabolism and disposition: the biological fate of chemicals 47 (10) (2019)
Katsuaki Ito, Noora Sjöstedt, Kim L R Brouwer
Mechanistic Modeling of the Hepatic Disposition of Estradiol-17β-Glucuronide in Sandwich-Cultured Human Hepatocytes. Drug metabolism and disposition: the biological fate of chemicals 48 (2) (2019)
Izna Ali, Seher Khalid, Bruno Stieger, Kim L R Brouwer
Effect of a Common Genetic Variant (p.V444A) in the Bile Salt Export Pump on the Inhibition of Bile Acid Transport by Cholestatic Medications. Molecular pharmaceutics 16 (3) (2019)
James J Beaudoin, Jacqueline Bezençon, Yanguang Cao, Katsuhiko Mizuno, Sharin E Roth, William J Brock, Kim L R Brouwer
Altered Hepatobiliary Disposition of Tolvaptan and Selected Tolvaptan Metabolites in a Rodent Model of Polycystic Kidney Disease. Drug metabolism and disposition: the biological fate of chemicals 47 (2) (2018)
Virginia D Schmith, Kellie Schoolar Reynolds, Kim L R Brouwer, Paolo Vicini
A Challenge for Clinical Pharmacologists: How Can We Measure Scientific Impact of Publications in Drug Development and in Regulatory Decision Making? Clinical pharmacology and therapeutics 105 (5) (2018)
Melina M Malinen, Izna Ali, Jacqueline Bezençon, James J Beaudoin, Kim L R Brouwer
Organic solute transporter OSTα/β is overexpressed in nonalcoholic steatohepatitis and modulated by drugs associated with liver injury. American journal of physiology. Gastrointestinal and liver physiology 314 (5) (2018)