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Deficiency of TOP1MT enhances glycolysis through the stimulation of PDK4 expression in gastric cancer.
Hongqiang Wang
Xutao Sun
Chen Yang
Ziqi Li
Danwen Jin
Wenwen Zhu
Ze Yu
Published in:
Cancer & metabolism (2024)
In brief, our work demonstrated the critical function of TOP1MT in the regulation of glycolysis by PDK4 in gastric cancer. Inhibiting glycolysis and limiting tumor metastasis in GC may be accomplished by suppressing PDK4.
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