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Phase I/Ib, open-label, multicenter, dose-escalation study of the anti-TGF-β monoclonal antibody, NIS793, in combination with spartalizumab in adult patients with advanced tumors.

Todd M BauerArmando SantoroChia-Chi LinIgnacio Garrido-LagunaMarkus JoergerRichard GreilAnna SpreaficoThomas YauMaria-Elisabeth GoebelerMarie Luise Hütter-KrönkeAntonella PerottiPierre-Eric JuifDarlene LuLouise BarysViviana CremascoMarc PelletierHelen EvansClaire FabreToshikiko Doi
Published in: Journal for immunotherapy of cancer (2023)
NCT02947165.
Keyphrases
  • monoclonal antibody
  • open label
  • clinical trial
  • phase ii
  • transforming growth factor
  • squamous cell carcinoma
  • cross sectional
  • signaling pathway
  • childhood cancer