Germline USP36 mutation confers resistance to EGFR-TKIs by upregulating MLLT3 expression in non-small cell lung cancer patients.

Shaoxing Guan Xi Chen Yuru Wei Fei Wang Wen Xie Youhao Chen Heng Liang Xia Zhu Yunpeng Yang Wenfeng Fang Yan Huang Hongyun Zhao Xiao-Xu Zhang Shu Liu Wei Zhuang Min Huang Xue-Ding Wang Li Zhang

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

These findings characterized rs3744797 as an oncogenic variant in mediating EGFR-TKIs resistance and tumor aggressiveness through deubiquitinating MLLT3, highlighting the variant as a predictive biomarker for EGFR-TKIs response in NSCLC.

Keyphrases

small cell lung cancer
epidermal growth factor receptor
tyrosine kinase
advanced non small cell lung cancer
poor prognosis
brain metastases
single cell
transcription factor
cell therapy
dna repair
binding protein
dna damage
mesenchymal stem cells
bone marrow