Predictors of Current DSM-5 PTSD Diagnosis and Symptom Severity Among Deployed Veterans: Significance of Predisposition, Stress Exposure, and Genetics.

Yirui HuXin ChuThomas G UrosevichStuart N HoffmanH Lester Kirchner Richard E Adams Ryan J DuganJoseph J BoscarinoWeixing ShiCarrie A Withey Charles R FigleyJoseph A Boscarino

Published in: Neuropsychiatric disease and treatment (2020)

Both warzone and non-warzone factors predicted current PTSD symptoms among veterans, including a PTSD genetic risk score. Interaction effects were detected for combat exposure and lifetime trauma by genetic risk score for PTSD symptoms, suggesting that PTSD symptom manifestation was more dependent on PTSD risk variants than the level of trauma or combat exposure. This suggests that controlling for other factors, the absence of genetic risk variants may confer PTSD resilience. Further research is planned.

Keyphrases

posttraumatic stress disorder
social support
copy number
genome wide
depressive symptoms
sleep quality
stress induced