Mutational Landscape and Expression of PD-L1 in Patients with Non-Small Cell Lung Cancer Harboring Genomic Alterations of the MET gene.
Alessa FischerLorenz BankelStefanie HiltbrunnerMarkus RechsteinerJan H RüschoffElisabeth Jane RushingChristian BritschgiAlessandra Curioni-FontecedroPublished in: Targeted oncology (2022)
We demonstrated that MET exon 14 skipping alterations and MET amplification are not mutually exclusive to other oncogenic co-mutations, and report the association of genomic MET alterations with PD-L1 expression. Since genomic MET alterations are emerging targets requiring upfront treatment, optimal understanding of the co-mutational landscape for this patient population is needed.