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Mutational Landscape and Expression of PD-L1 in Patients with Non-Small Cell Lung Cancer Harboring Genomic Alterations of the MET gene.

Alessa FischerLorenz BankelStefanie HiltbrunnerMarkus RechsteinerJan H RüschoffElisabeth Jane RushingChristian BritschgiAlessandra Curioni-Fontecedro
Published in: Targeted oncology (2022)
We demonstrated that MET exon 14 skipping alterations and MET amplification are not mutually exclusive to other oncogenic co-mutations, and report the association of genomic MET alterations with PD-L1 expression. Since genomic MET alterations are emerging targets requiring upfront treatment, optimal understanding of the co-mutational landscape for this patient population is needed.
Keyphrases
  • tyrosine kinase
  • copy number
  • poor prognosis
  • single cell
  • case report
  • transcription factor
  • long non coding rna
  • replacement therapy
  • smoking cessation