FcεRI expression and IgE binding by dendritic cells and basophils in allergic rhinitis and upon allergen immunotherapy.
M BeringsP GevaertN De RuyckL DeryckeG HoltappelsC PiletteC BachertB N LambrechtMelissa DullaersPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2018)
This study provides a comprehensive insight into the relation between serum IgE and FcεRI/IgE on basophils and DC subsets. The novel finding that HDM SCIT induces a temporary increase in FcεRI expression on DCs, but not on basophils, can be an incentive for future research on the potential tolerogenic role of IgE/FcεRI signalling in DCs in the setting of allergen immunotherapy.