Fatty acids and selected endocannabinoids content in cerebrospinal fluids from patients with neuroinfections.
Jacek CzepielJoanna Gdula-ArgasińskaGrażyna BiesiadaBeata BystrowskaArtur JurczyszynWilliam PeruckiKatarzyna SroczyńskaAnna ZającTadeusz LibrowskiAleksander GarlickiPublished in: Metabolic brain disease (2018)
Neuroinfections are a significant medical problem and can have serious health consequences for patients. Their outcome, if not fatal, can be associated with permanent residual deficits. Cerebrospinal fluid (CSF) examination is commonly used for meningitis confirmation. Fatty acids (FA) are precursors of lipid mediators with pharmacological activity. They actively modulate inflammation as well as contribute to its resolution. Therefore the aim of this study was to determine the FA and selected endocannabinoids (ECB) content in the CSF obtained from patients with bacterial (BM) and viral meningitis (VM) using chromatographic techniques. A significantly lower level of saturated FA was found in patients with BM and VM as compared to controls. There was a significantly higher concentration of long-chain monounsaturated FA and polyunsaturated n-6 FA in the CSF obtained from patients with neuroinfection. Moreover, a significant reduction of n-3 FA in CSF obtained from patients with BM and VM was demonstrated. The highest amount of ECB was detected in the CSF of patients with VM: eicosapentaenoyl ethanolamide (1.65 pg/mL), docosahexaenoyl ethanolamide (655.5 pg/mL) and nervonoyl ethanolamide (3.09 ng/mL). Results indicate the participation of long-chain monounsaturated and polyunsaturated FA and their derivatives in the inflammatory process and likely in the process of resolution of inflammation during neuroinfection. It seems that the determination of the FA and ECB profile in CSF may be a valuable biomarker of health and may allow the development of new pharmacological strategies, therapeutic goals and fatty acids supplementation necessary in the fight against inflammation of the central nervous system.
Keyphrases
- fatty acid
- cerebrospinal fluid
- oxidative stress
- healthcare
- public health
- end stage renal disease
- mental health
- newly diagnosed
- ejection fraction
- physical activity
- sars cov
- health information
- peritoneal dialysis
- chronic kidney disease
- single molecule
- risk assessment
- patient reported outcomes
- climate change
- human health