Prehospital Tranexamic Acid for Severe Trauma.
null nullRussell L GruenBiswadev MitraStephen A BernardColin J McArthurBrian BurnsDashiell C GantnerMarc MaegelePeter A CameronBridget L DickerAndrew B ForbesSally HurfordCatherine A MartinStefan M MazurRobert L MedcalfLynnette J MurrayPaul S MylesSze J NgVeronica PittStephen RashfordMichael C ReadeAndrew H SwainTony TrapaniPaul Jeffrey YoungPublished in: The New England journal of medicine (2023)
Among adults with major trauma and suspected trauma-induced coagulopathy who were being treated in advanced trauma systems, prehospital administration of tranexamic acid followed by an infusion over 8 hours did not result in a greater number of patients surviving with a favorable functional outcome at 6 months than placebo. (Funded by the Australian National Health and Medical Research Council and others; PATCH-Trauma ClinicalTrials.gov number, NCT02187120.).