T cell exhaustion dynamics in systemic autoimmune disease.
Christi N TurnerJuan Camilo Sánchez-ArcilaNoah HuertaAvi Rae QuiguoeKirk D C JensenKatrina K HoyerPublished in: bioRxiv : the preprint server for biology (2023)
CXCR5- and CXCR5+ CD8 T cells expand with rate of disease in SLE mouse model.CXCR5+ CD8 T cells are low contributors to TNFα disease progression unlike CXCR5-CD8 T cells but may increase disease mechanisms through high IFNγ production.Inhibitory markers upregulate in frequency with the highest amounts seen in Tim3+ populations. Tim3+Lag3+ expression may be an indicator of terminal differentiation for all populations.Inhibitory marker expression frequency was unrelated to sex.