Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer.

Vladislav KorobeynikovMichelle BorakoveYayi FengWilliam M WuestAlex B KovalAnna S NikonovaIlya SerebriiskiiJonathan ChernoffVirginia F BorgesErica A GolemisElena Shagisultanova

Published in: Breast cancer research and treatment (2019)

Dual targeting of AURKA and PAK1 may be a promising therapeutic strategy for treatment of breast cancer, with a particular effectiveness in luminal and HER2-enriched tumor subtypes.

Keyphrases

randomized controlled trial
systematic review
combination therapy
tyrosine kinase
replacement therapy