Fatigability in spinal muscular atrophy: validity and reliability of endurance shuttle tests.

Bart BartelsJanke F de GrootLaura E HabetsCamiel A WijngaardeWendy VinkMarloes StamFay-Lynn AsselmanRuben P A van EijkW Ludo van der Pol

Published in: Orphanet journal of rare diseases (2020)

Fatigability is an important additional dimension of physical impairments across the severity spectrum in children and adults with SMA. The EST's are reliable and valid to document fatigability of walking, proximal- and distal arm function in SMA and thus are promising outcome measures for use in clinical trials.

Keyphrases

clinical trial
young adults
physical activity
skeletal muscle
mental health
high intensity
randomized controlled trial
resistance training
open label
study protocol
body composition