Physical Activity and Insulin Sensitivity Independently Attenuate the Effect of FTO rs9939609 on Obesity.

Mette K AndersenLars ÄngquistJette Bork-JensenAnna E JonssonSara Elizabeth StinsonCamilla H SandholtMalte ThodbergLaura Maarit PikkupeuraEmily L OngstadNiels GrarupArne AstrupOluf PedersenKristine WilliamsRomain BarresThorkild I A SørensenAllan LinnebergJoseph GrimsbyChristopher J RhodesTorben Hansen

Published in: Diabetes care (2023)

Greater PA and IS independently reduced the effect of rs9939609 on obesity. These effects might be mediated through altered expression of FTO in skeletal muscle. Our results indicated that PA and/or other means of increasing insulin sensitivity could counteract FTO-related genetic predisposition to obesity.

Keyphrases

insulin resistance
metabolic syndrome
skeletal muscle
weight loss
high fat diet induced
type diabetes
physical activity
weight gain
poor prognosis
adipose tissue
body mass index
genome wide
gene expression
long non coding rna
depressive symptoms
copy number