Apolipoprotein E epsilon 4 (APOE-ε4) genotype is associated with decreased 6-month verbal memory performance after mild traumatic brain injury.
John K YueCaitlin K RobinsonJohn F BurkeEthan A WinklerHansen DengMaryse C CnossenHester F LingsmaAdam R FergusonThomas W McAllisterJonathan RosandEsteban G BurchardMarco D SoraniSourabh SharmaJessica L NielsonGabriela G SatrisJason F TalbottPhiroz E TaraporeFrederick K KorleyKevin K W WangEsther L YuhPratik MukherjeeRamon Diaz-ArrastiaAlex B ValadkaDavid O OkonkwoGeoffrey T Manleynull nullPublished in: Brain and behavior (2017)
The APOE-ε4 allele may confer an increased risk of impairment of 6-month verbal memory for patients suffering mTBI, with implications for heightened surveillance and targeted therapies. Acute intracranial pathology remains the driver of decreased verbal memory performance at 6 months after mTBI.
Keyphrases
- working memory
- mild traumatic brain injury
- end stage renal disease
- cognitive decline
- ejection fraction
- newly diagnosed
- chronic kidney disease
- high fat diet
- liver failure
- public health
- peritoneal dialysis
- drug induced
- adipose tissue
- type diabetes
- optical coherence tomography
- mild cognitive impairment
- skeletal muscle
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation
- mechanical ventilation