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Genomic Profiling of Rare Undifferentiated Sarcomatoid Subtypes of Pancreatic Carcinomas: In Search of Therapeutic Targets.

Erik B FaberHarris B KrauseKhalid AminPhilip WalkerPeter J HoseinAnthony Frank ShieldsHeinz-Josef LenzAjay PrakashSanjay GoelMatthew J OberleyGiuseppe MalleoClaudio LuchiniJustin H HwangVaia FlorouIgnacio Garrido-LagunaEmil Lou
Published in: JCO precision oncology (2024)
To our knowledge, this work represents the largest molecular analysis of USC tumors to date and showed an increased expression of immune checkpoint genes in USC tumors. These findings provide evidence for further investigation into immune checkpoint inhibitors in USC tumors.
Keyphrases
  • poor prognosis
  • healthcare
  • single cell
  • gene expression
  • high grade
  • copy number
  • long non coding rna
  • dna methylation
  • transcription factor
  • genome wide identification
  • bioinformatics analysis