Effects of sidechain isomerism on polymer-based non-covalent protein delivery.
Alfonso BarriosMario MilanElianny PerozoMd Lokman HossenPrem P ChapagainJoong Ho MoonPublished in: Chemical communications (Cambridge, England) (2022)
We present the importance of functional group isomerism on intracellular protein delivery using polymers containing different isomeric side chains. While the physical properties of polymer/protein complexes are relatively similar, different planarity of the isomers greatly influences the cellular entry efficiency.