BIRC3 Expression Predicts CLL Progression and Defines Treatment Sensitivity via Enhanced NF-κB Nuclear Translocation.

Daniela AsslaberNathalie WachtMichael LeischYuan QiNicole MaedingClemens HufnaglBettina JanskoNadja ZaborskyAndreas VillungerTanja N HartmannRichard GreilAlexander Egle

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

Here we show the impact of BIRC3 expression in CLL disease progression in the absence of BIRC3 mutations and show altered canonical NF-κB target gene activation with therapeutic implications.

Keyphrases

poor prognosis
signaling pathway
lps induced
oxidative stress
pi k akt
nuclear factor
binding protein
long non coding rna
copy number
inflammatory response
dna methylation
transcription factor