Circulating Receptor Activator of Nuclear Factor kB Ligand and triglycerides are associated with progression of lower limb arterial calcification in type 2 diabetes: a prospective, observational cohort study.
Olivier BourronFranck PhanMamadou Hassimiou DialloDavid HajageCarole-Elodie AubertAurélie CarlierJoe-Elie SalemChristian Funck-BrentanoSalim KemelPhilippe CluzelAlban RedheuilJean-Michel DavaineZiad MassyRomuald MentaverriDominique Bonnefont-RousselotPhilippe GilleryStéphane JaissonCees VermeerJean-Marc LacorteNesrine BouziriSuzanne LarocheChloé AmouyalAgnes HartemannPublished in: Cardiovascular diabetology (2020)
In patients with type 2 diabetes, lower limb arterial calcification is frequent and can progress rapidly. Circulating RANKL and triglycerides are independently associated with this progression. These results open new therapeutic perspectives in peripheral diabetic calcifying arteriopathy. Trial registration NCT02431234.