Adamantinomatous Craniopharyngioma in an Adult: A Case Report with NGS Analysis.
Raid A JastaniaMuhammad SaeedHisham Al-KhalidiKhalid M AlquthamiTahani H NageetiFaisal A Al-AllafKristoffer ValerieMohiuddin M TaherPublished in: International medical case reports journal (2020)
As reported in previous studies, in ACP tumors we found a CTNNB1 mutation by NGS analysis. The PIK3CA variants we detected were not known previously in ACP tumors. Finding the PIK3CA mutations in the ACP tumors may help develop targeted therapy for a subset of craniopharyngiomas with PIK3CA activating mutations. Clinical trials are in progress with specific PIK3CA inhibitors in advanced stages of many cancers.