Nano-scaled emulsion and nanogel containing Mentha pulegium essential oil: cytotoxicity on human melanoma cells and effects on apoptosis regulator genes.
Sareh AzadiMahmoud OsanlooElham ZarenezhadMojtaba FarjamAkram JalaliAli GhanbariasadPublished in: BMC complementary medicine and therapies (2023)
The results showed that cell viability was reduced by 90 and 45% after treatment with 300 μg/mL of the nanogel and nano-scaled emulsion. As confirmed by flow cytometry, this effect was mediated by apoptosis. Furthermore, gene expression analysis showed up-regulation of Bax and down-regulation of Bcl-2 genes. Therefore, the prepared nanogel, with high efficacy, could be considered a potent anticancer agent for supplementary medicine and in vivo research.
Keyphrases
- genome wide identification
- flow cytometry
- essential oil
- transcription factor
- genome wide
- endoplasmic reticulum stress
- oxidative stress
- cell cycle arrest
- cell death
- endothelial cells
- induced apoptosis
- genome wide analysis
- bioinformatics analysis
- dna methylation
- copy number
- induced pluripotent stem cells
- pluripotent stem cells
- gene expression
- pi k akt