The important biological roles of Syncytin-1 of human endogenous retrovirus W (HERV-W) and Syncytin-2 of HERV-FRD in the human placenta development.

Mehdi Gholami BarzokiSomayeh Shatizadeh MalekshahiZahra HeydarifardMohamad Javad MahmodiHaleh Soltanghoraee

Published in: Molecular biology reports (2023)

Interestingly, it has been suggested that syncytins may also be implicated in non-fusogenic activities leading to apoptosis, proliferation, and immunosuppressive activities.

Keyphrases

endothelial cells
pluripotent stem cells
oxidative stress
signaling pathway
cell death
endoplasmic reticulum stress
pi k akt