Estimation of sample size in randomized controlled trials in multiple sclerosis studying annualized relapse rates: A systematic review.

Louis Poncet-MegemontBruno PereiraFabien RollotMaria Pia SormaniPierre ClavelouXavier Moisset

Published in: Multiple sclerosis (Houndmills, Basingstoke, England) (2021)

SSE was rarely performed using the most appropriate model. However, the use of an NB model is recommended to optimize the number of included patients and to be congruent with the final analysis.

Keyphrases

multiple sclerosis
end stage renal disease
randomized controlled trial
newly diagnosed
ejection fraction
chronic kidney disease
peritoneal dialysis
prognostic factors
systematic review
clinical trial
patient reported