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Ketamine for Critically Ill Patients with Severe Acute Brain Injury: A Systematic Review with Meta-analysis and Trial Sequential Analysis of Randomized Clinical Trials.

Trine Hjorslev AndreasenFrederik Andreas MadsenMarija BarbateskovicJane LindschouChristian GluudKirsten Møller
Published in: Neurocritical care (2024)
The level of evidence regarding the effects of ketamine on functional outcome and serious adverse events in patients with severe acute brain injury is very low. Ketamine may markedly, modestly, or not at all affect these outcomes. Large randomized clinical trials at low risk of bias are needed.
Keyphrases
  • brain injury
  • subarachnoid hemorrhage
  • pain management
  • cerebral ischemia
  • clinical trial
  • study protocol
  • phase iii
  • randomized controlled trial
  • chronic pain
  • skeletal muscle
  • double blind
  • blood brain barrier