Wnt-driven LARGE2 mediates laminin-adhesive O-glycosylation in human colonic epithelial cells and colorectal cancer.

Vanessa DietingerCira R García de DurangoSvenja WiechmannSophie L BoosMarlies MichlJens NeumannHeiko HermekingBernhard KusterPeter Jung

Published in: Cell communication and signaling : CCS (2020)

We conclude that the LARGE2 O-glycosyltransferase-encoding gene represents a direct target of canonical Wnt signaling and mediates functional O-glycosylation of α-dystroglycan (α-DG) in human colonic stem/progenitor cells and Wnt-driven CRC. Our work implies that aberrant Wnt activation augments CRC cell-matrix adhesion by increasing LARGE/α-DG-mediated laminin-adhesiveness. Video abstract.

Keyphrases

endothelial cells
stem cells
cell proliferation
induced pluripotent stem cells
pluripotent stem cells
single cell
cell therapy
ulcerative colitis
escherichia coli
bone marrow
dna methylation
genome wide identification