IRF7 gene expression profile and methylation of its promoter region in patients with systemic sclerosis.

Ramazan RezaeiMahdi MahmoudiFarhad GharibdoostHoda KavosiNavid DashtiVahideh ImeniAhmadreza JamshidiSaeed AslaniShayan MostafaeiMohammad Vodjgani

Published in: International journal of rheumatic diseases (2017)

It is suggested that hypomethylation of the IRF7 promoter might play a role in SSc pathogenesis, probably through promoting the IRF7 expression in PBMCs of patients with SSc.

Keyphrases

systemic sclerosis
gene expression
dna methylation
interstitial lung disease
dendritic cells
genome wide
poor prognosis
transcription factor
rheumatoid arthritis
binding protein
long non coding rna