Immunization with cytolethal distending toxin B produces autoantibodies to vinculin and small bowel bacterial changes in a rat model of postinfectious irritable bowel syndrome.

Walter MoralesKonstantinos TriantafyllouGonzalo ParodiStacy WeitsmanSung Chul ParkAli RezaieNipaporn PichetshoteEugenia LinMark Pimentel

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2020)

Rats injected with CdtB developed a postinfectious IBS-like phenotype and autoimmunity to vinculin with corresponding reduction in intestinal vinculin expression.

Keyphrases

irritable bowel syndrome
small bowel
poor prognosis
escherichia coli
systemic lupus erythematosus
binding protein