Drugs Repurposed as Antiferroptosis Agents Suppress Organ Damage, Including AKI, by Functioning as Lipid Peroxyl Radical Scavengers.

Eikan MishimaEmiko SatoJunya ItoKen-Ichi YamadaChitose SuzukiYoshitsugu OikawaTetsuro MatsuhashiKoichi KikuchiTakafumi ToyoharaTakehiro SuzukiSadayoshi ItoKiyotaka NakagawaTakaaki K Abe

Published in: Journal of the American Society of Nephrology : JASN (2019)

Although elevated lipid peroxyl radical levels can trigger ferroptosis onset, some drugs that scavenge lipid peroxyl radicals can help control ferroptosis-related disorders, including AKI.

Keyphrases

acute kidney injury
cell death
fatty acid
oxidative stress
drug induced